Vitamin & Herb University
Vitamin Information Minerals Information Dietary Supplement Information Herb Information Drug Herb Interaction Continuing Education Pharmacy
Vitamin & Herb University
Chromium

Red Arrow  Facts Red Arrow  Functions
Red Arrow  Requirements & Recommendations Red Arrow  Deficiency signs and symptoms
Red Arrow  Toxicity Red Arrow  Dietary Sources
Red Arrow  Populations w/ Special Needs Red Arrow  Drug-Mineral Interaction
Red Arrow  Research Summary

Print this page Print this page
Contact an Expert Contact an Expert
Dosage Chart  Dosage Chart

Facts

  • Chromium (Cr) is an essential trace element for humans.
  • Chromium exists in nature in oxidation states ranging from Cr0 to Cr+6. The predominant forms are Cr+3 and Cr+6 (trivalent and hexavalent, respectively). Cr+6 is a strong oxidizing agent that is readily reduced to Cr+3 under acidic conditions such as the stomach. Cr+3 has a wide range of safety, while Cr+6 and Cr+4 have significant potential for toxicity.
  • Chromium absorption and utilization are influenced by other dietary factors such as chelating agents and conditions such as age and diabetes. Phytate, oxalate, and ascorbate promote Cr absorption.
  • Chromium absorption is generally low, approximately 0.4 – 2.0%. The percentage of dietary Cr absorbed decreases as the amount consumed increases. Excretion occurs through the kidney, with small amounts lost in hair, sweat and bile.


  • Functions

    • Chromium is distributed throughout the body, although studies and evidence regarding distribution are limited.
    • Research has shown Cr+3 to potentiate insulin action.
    • Cr+3 may stabilize nucleic acids (mainly RNA) against structural distortions.
    • Cr+3 may stimulate synthesis of fatty acids and cholesterol in the liver.
    • Glucose tolerance factor (GTF) contains Cr3+ and works like a hormone, along with insulin, to facilitate glucose transport from blood into the cells of various tissues. GTF also enhances intracellular metabolism of nutrients. In vitro studies found that GTF binds insulin-activated insulin receptors, stimulates tyrosine kinase activity and potentiates the activity of insulin


  • Requirements & Recommendations

    Chromium: Dietary Reference Intake:1
    mcg/day
    Infants
    0 to 6 months
    7 to 12 months
    0.25
    .5
    Children
    1 to 3 years
    4 to 8 years
    11
    15
    Males
    9 to 13 years
    14 to 50 years
    51+ years
    Females
    9 to 13 years
    14 to 18 years
    19 to 50 years
    51+ years
    25
    35
    30

    21
    24
    25
    20
    Pregnancy
    <= 18 years
    19 to 50 years
    29
    30
    Lactation
    <= 18 years
    19 to 50 years
    44
    45


    * Values are Adequate Intakes (AI). Tolerable Upper Intake Levels (UL) are not determinable due to lack of data of adverse effects.


  • Deficiency signs and symptoms

    • The primary sign of chromium deficiency is glucose intolerance typified by high blood sugar and insulin concentrations, especially in elderly.
    • In humans, chromium deficiency may also result in glucosuria, weight loss, elevated plasma free fatty acid concentrations, neuropathy, and altered nitrogen metabolism.


  • Toxicity

    2
    • Cr+3 can cause gastric irritation at extremely high doses.
    • In Chinese hamster ovary cells, chromium picolinate (Cr+3) showed mutagenic activity. However, the amount used was 1000 times higher than that usually found in human circulation.
    • The Estimated Safe and Adequate Daily Dietary Intake (ESADDI) is 50 - 200 mcg for adults.
    • The reference dose (RfD) for Cr+3 set by the Environmental Protection Agency is 1.47 mg/kg. RfD for adults should be ~ 70 mg, which is 350 times higher than the ESADDI (50 - 200 mcg/day). 56


  • Dietary Sources

    Foods with high chromium concentrations include: processed meats, ready-to-eat bran cereals, broccoli, whole-grain products, green beans, and many spices.


  • Populations w/ Special Needs

    • Individuals with glucose intolerance and insulin insensitivity may benefit from additional chromium.
    • Chromium needs increase during pregnancy and lactation.


  • Drug-Mineral Interaction

    7 8 9
    • Supplementation of chromium and other nutrients often improves blood-sugar control in diabetic patients. In such cases, the dose of insulin or other antihyperglycemic agents may need to be reduced in order to avoid a hypoglycemic reaction. Consult with the prescribing physician before making dietary changes or taking nutrients.
    • Calcium carbonate and antacids tend to decrease the absorption of chromium. It is advisable to take chromium supplements 2 hours before or 4 hours after taking medications or other supplements.
    Information on the relationship between substances and disease is provided for general information, in order to convey a balanced review of the scientific literature. In many cases the relationship between a substance and a disease is tentative and additional research is needed to confirm such a relationship.


  • Research Summary

    Topic: Weight loss/muscle building

    Effects of chromium picolinate supplementation on body composition, strength, and urinary chromium loss in football players.
    The effect of chromium picolinate supplementation on body composition, strength, and urinary chromium loss was investigated. Thirty-eight football players were randomly assigned in a double-blind format to receive either 200 mcg chromium picolinate or a placebo for nine weeks during spring training. Participants receiving chromium supplements had significant increases in urinary chromium excretion. No changes in body composition or strength were found. The results of this study agree with previous investigations of the effects of chromium on body composition.10
    Red Arrow Read Abstract
    Topic: Gestational diabetes

    Chromium supplementation for women with gestational diabetes mellitus.
    Researchers at Sonsum Medical Research Institute studied the effects of chromium supplementation on gestational diabetes. Thirty women participated in the 8 week study; 10 received 2 mcg Cr picolinate/kg body weight/day, 10 received a placebo, and 10 received 8 mcg Cr picolinate/kg body weight/day. Their results showed that 2 - 8 mcg/kg/body weight/day of Cr picolinate improved postprandial glucose concentrations and reduced hyperinsulinemia in women with gestational diabetes.11
    Topic: Type 2 diabetes

    Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial.
    A 6-month randomized, double-blind, placebo-controlled trial investigated the effect of chromium supplementation in 46 obese people with poorly controlled type 2 diabetes. Subjects selected for the study had elevated HbA1c levels and required 50 units of insulin per day. Participants were randomized to receive 500 mcg chromium picolinate, 1000 mcg chromium picolinate, or a placebo daily. At the end of the trial, the reduction in HbA1c concentrations was approximately 0.4% in all groups. There was, however, a weak association between serum chromium concentration and improved lipid profile. This study did not find evidence to support a beneficial effect of chromium supplementation for obese people with poorly controlled type 2 diabetes. 3
    Red Arrow Read Abstract

    Effects of acute chromium supplementation on postprandial metabolism in healthy young men.
    Chromium supplementation potentiates the activity of insulin and can improve glucose tolerance. To investigate the possible glycemic index lowering effects of chromium, a randomized crossover design study was undertaken. Thirteen healthy young men participated in the three test meals (containing 75 g available carbohydrate with 400 mcg Cr picolinate, 800 mcg Cr picolinate, or placebo), with one week washout periods between each trial. Chromium supplementation (400 or 800 mcg) reduced capillary glucose by 23% and 20%, respectively, compared to carbohydrate alone. Interestingly, the trial revealed the presence of responders (10 subjects) who had significantly different glucose levels after chromium supplementation and nonresponders (3 subjects) who demonstrated no significant differences with supplementation. For the responders, capillary glucose was reduced by 36% and 30%, respectively, after supplementation with 400 or 800 mcg chromium. This study demonstrated that acute chromium supplementation could alter postprandial glucose metabolism for responders.17
    Red Arrow Read Abstract

    The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial.
    A recent randomized, double-blind, placebo-controlled study investigated the effects of chromium chloride supplemented milk on glycemic control in type 2 diabetes. Sixty people with type 2 diabetes, aged 30 to 75 years, were randomly assigned to receive either chromium supplemented milk (200 mcg chromium/20 g milk powder) or placebo twice daily for 16 weeks. The chromium supplemented group had lower fasting plasma glucose, fasting insulin, and improved metabolic control, especially in male patients. The data indicate that chromium supplementation may be useful for people with type 2 diabetes.16
    Red Arrow Read Abstract

    Chromium supplementation does not improve glucose tolerance, insulin sensitivity, or lipid profile: a randomized, placebo-controlled, double-blind trial of supplementation in subjects with impaired gl
    Forty people with impaired glucose tolerance (IGT) enrolled in a study to investigate the effects of chromium on glucose tolerance, insulin sensitivity, and lipid profiles. Half received 800 mcg/day of chromium picolinate for three months and the other half received a placebo. After three months, no significant benefits from supplementation were evident. Two statistically significant changes were noted during the study: an increase in serum chromium concentration in the supplemented group and a slight, but significant, increase in total cholesterol in the placebo group. This small study found no benefit from chromium picolinate supplementation.14

    Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes.
    A double-blind, placebo-controlled study of 180 people with type 2 diabetes was conducted to determine whether chromium supplementation plays a role in glycemic control. High doses of chromium (1000 mcg/day) significantly improved glycemic control as compared to placebo. Plasma total cholesterol concentration decreased in subjects consuming 1000 mcg of chromium per day after 4 months. Low doses of chromium (200 mcg/day) decreased fasting insulin, 2-hour insulin values and hemoglobin HbA1c, but did not lower plasma cholesterol concentration. 12
    Red Arrow Read Abstract
    Topic: Cardiovascular health

    Low toenail chromium concentration and increased risk of nonfatal myocardial infarction.
    In eight European countries and Israel, a study was conducted with men after diagnosis of first myocardial infarction (684 cases versus 724 controls) to evaluate the effect of chromium status on risk of myocardial infarction. Chromium status was determined from chromium content of toenails by neutron activation analysis. Average chromium concentrations were 1.10 mcg/g for cases and 1.30 mcg/g for controls. The relative risk of myocardial infarction was 0.82 for the second quintile and 0.59 for the highest quintile. There was an inverse association between toenail chromium concentration and risk of myocardial infarction. More trials are necessary to further investigate this association.13
    Red Arrow Read Abstract
    Topic: Polycystic ovary disease

    Chromium picolinate improves insulin sensitivity in obese subjects with polycystic ovary syndrome.
    A small study investigated the effect of 1000 mcg chromium picolinate daily on glucose disposal rate. Five obese women with polycystic ovary syndrome participated in the study. Supplementation with daily chromium resulted in a mean 38% reduction in glucose disposal rate. The authors concluded that chromium supplements may be useful insulin sensitizers for treatment of polycystic ovary syndrome. Larger studies are required to further investigate this result.15
    Red Arrow Read Abstract
    Arrow top back to top


    Reference box top left Reference header box help Reference box top right
    Reference box side
    Bullets Herbs (1 reference)
     View my references
    To save references
    you must be logged in.
    Click Here to log in.
    Reference box side
    Reference box bottom left Reference box side Reference box bottom right