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White Willow Bark

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 Drug-Herb Interaction Topic header down arrow
  • While no substantial interactions have been reported to date, salicylate containing herbs such as white willow bark may interact with aspirin, aspirin-containing drugs, or other salicylates such as bismuth subsalicylate (BSS, Pepto-Bismol, and others){~1~}{~2~}{~3~}.

Information on the relationship between substances and disease is provided for general information, in order to convey a balanced review of the scientific literature. In many cases the relationship between a substance and a disease is tentative and additional research is needed to confirm such a relationship.
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 Facts Topic header down arrow
  • Hippocrates was the first to document the beneficial effects of willow bark.
  • Willow bark can diminish a fever, reduce inflammation, and alleviate pain.
  • Salicin and salicylic acid are both found in willow bark and are precursors to aspirin (acetylsalicylic acid).
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 Functions Topic header down arrow
  • Salicin is thought to be the principal active component in willow bark extracts.
  • Salicin and other components of willow bark have fever-reducing, antioxidant, anti-inflammatory, and analgesic effects
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 Dosage Topic header down arrow
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 Toxicity Topic header down arrow
Not known. People with known aspirin allergies should avoid salicylate containing supplements such as those derived from willow as they may elicit an allergic reaction
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 Research Summary Topic header down arrow
Topic: Arthritis

Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial.
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Topic:  Low back pain

Treatment of low back pain with an herbal or synthetic anti-rheumatic: a randomized controlled study. Willow bark extract for low back pain
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Potential economic impact of using a proprietary willow bark extract in outpatient treatment of low back pain: an open non-randomized study
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Treatment of low back pain exacerbation with willow bark extract: a randomized double-blind study.
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Topic: Collagen formation

Heat shock protein 47 expression in aged normal human fibroblasts: modulation by Salix alba extract.
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 Uses Topic header down arrow
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